Plasma Protein Binding
Generally, only the unbound drug is available for diffusion or transport across cell membranes, and also for interaction with a pharmacological target. As a result, a degree of plasma protein binding of a drug influences not only on the drug’s action but also its disposition and efficacy. In PreADMET can predict percent drug bound in plasma protein as in vitro data on human.
Although there are some differences in the experimental values by compounds or their metabolisms, we can put into general categories like below.
|Classification||Plasma Protein Binding(%PPB)|
|Chemicals strongly bound||more than 90%|
|Chemicals weakly bound||less than 90%|